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Tipifarnib S enantiomer
CAS No. 192185-71-0
Tipifarnib S enantiomer( S)-(-)-R-115777 | IND-58359 S enantiomer )
Catalog No. M13012 CAS No. 192185-71-0
Tipifarnib S enantiomer is a potent and selective inhibitor of FTase (farnesyltransferase).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 104 | In Stock |
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| 5MG | 163 | In Stock |
|
| 10MG | 263 | In Stock |
|
| 25MG | 473 | In Stock |
|
| 50MG | 683 | In Stock |
|
| 100MG | 963 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTipifarnib S enantiomer
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NoteResearch use only, not for human use.
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Brief DescriptionTipifarnib S enantiomer is a potent and selective inhibitor of FTase (farnesyltransferase).
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DescriptionTipifarnib S enantiomer is a potent and selective inhibitor of FTase (farnesyltransferase); inhibits the farnesylation of lamin B and K-RasB peptide substrates with IC50s of 0.86 nM and 7.9 nM, respectively; no activity for PGGT1(IC50>50 uM); shows sensiticity for tumor cell lines bearing H-ras or N-ras mutations; inhibits the growth of tumors bearing mice and orally bioavailable.Blood Cancer Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsS)-(-)-R-115777 | IND-58359 S enantiomer
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PathwayMetabolic Enzyme/Protease
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TargetFtase
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RecptorFtase
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number192185-71-0
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Formula Weight489.3958
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Molecular FormulaC27H22Cl2N4O
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1N(C)C2=C(C=C([C@](C3=CC=C(Cl)C=C3)(N)C4=CN=CN4C)C=C2)C(C5=CC=CC(Cl)=C5)=C1
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Chemical Name2(1H)-Quinolinone, 6-[(S)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. End DW, et al. Cancer Res. 2001 Jan 1;61(1):131-7.
2. Kelland LR, et al. Clin Cancer Res. 2001 Nov;7(11):3544-50.
3. Beaupre DM, et al. Mol Cancer Ther. 2004 Feb;3(2):179-86.
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